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Se dirige específicamente a la producción de hormonas sexuales, incluyendo la producción de testosterona. Todos los datos que dejarèis en nuestro sitio, estaràn protegidos por un sistema de seguridad. Los anabólicos naturales en polvo, además de ser económicos, permiten mezclarlos con tus batidos o tus preparados pre/post entreno y una dosificación personalizada, ajustando fácilmente la cantidad que necesites. Nuestra tienda on-line Anabol-es.com ofrece los precios más asequibles para todos.

También puedes unirte a nuestra comunidad de Telegram para recibir las ofertas diariamente. Estos productos están enfocados a hombres de una edad cercana a los 30 años o superior, donde se empiezan a notar síntomas como un metabolismo más lento, menos energía, disminución del apetito sexual, etcétera. Es un producto con poco tiempo en el mercado, pero que funciona bastante bien. No hemos tenido la oportunidad de probarlo a fondo, por lo que lo hemos incluido al final. Entre sus ingredientes incluye TESTOFEN, Tribulus Terrestris y Arginina AKG y Flavonoides. Si desea que su pedido permanezca lo más anónimo posible, especifique el número, en el que se encuentra uno de los mensajeros (Telegram, Viber.WhatsApp).

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Sin duda alguna, los precursores de testosterona naturales son una buenísima opción para todos aquellos que buscan optimizar los resultados al máximo. Os recomendamos leer nuestra guía definitiva para ganar fuerza y encontrar todos los suplementos que necesitas para crecer en el gimnasio. Muchos ingredientes disponibles en los precursores de testosterona naturales funcionan como reguladores o promotores. Estos reguladores funcionan mediante el uso de compuestos específicos, los cuales una vez dentro del cuerpo puede naturalmente señalar tu ADN para ser más eficiente en la producción de testosterona.

• Os recomendamos leer nuestra guía definitiva para ganar fuerza y encontrar todos los suplementos que necesitas para crecer en el gimnasio.
• Estas desventajas se pueden minimizar no sobrepasando las dosis recomendadas.
• Para saber exactamente qué fármaco elegir, debe conocer los posibles efectos positivos de los medicamentos, los efectos secundarios, la administración adecuada y los requisitos de dosificación de acuerdo con su propósito y objetivo de tomarlos.
• Además, son un buen suplemento para la ganancia de fuerza durante el entreno.

Al aumentar los niveles de testosterona en el cuerpo, se cree que el Tribulus Terrestris puede mejorar la fuerza muscular, aumentar la libido, mejorar la calidad del sueño y reducir la fatiga. Sin embargo, es importante tener en cuenta que los efectos del Tribulus Terrestris en la testosterona y en la salud en common no han sido completamente establecidos, y se necesitan más investigaciones para confirmar su eficacia y seguridad. ¡Bienvenido a nuestra tienda on-line de esteroides anabólicos, Anabol-es.com! ¿Estás cansado de los largos entrenamientos sin conseguir los resultados que deseas? Aquí puedes encontrar la solución – esteroides anabólicos, un remedio universal para el aumento acelerado de la masa muscular.

Descripción del producto Acetato de trembolona one hundred mg Magnus Pharmaceuticals Magnus Pharmaceutica.. Test P (Testosterone Propionate) a hundred mg Magnus Pharmaceuticals es un fármaco utilizado en el culturi.. Las ostras, almejas, berberechos y pipas de calabaza por su alto contenido en zinc. La primera depende mucho de una genética muscular, una rigurosa planificación nutricional a largo plazo, y unos ciclos de fuerza, definición y volumen muy calculados.

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Esto es posible con un estudio cuidadoso de todas las propiedades y características de los fármacos, así como las contraindicaciones de cada sustancia que puede ser necesaria en la práctica. Estas desventajas se pueden minimizar no sobrepasando las dosis recomendadas. Además, es aconsejable consultar previamente a un médico y someterse a un examen corporal completo. En función de los resultados obtenidos, un especialista podrá elaborar un plan óptimo, seleccionar los corticoides y responder a otras preguntas importantes.

Algunos ingredientes trabajan mejor que otros debido a que cada cuerpo es diferente y el código genético varía en cada individuo. Los precursores de testosterona promueven el incremento de testosterona a través de vías naturales, mejorando el funcionamiento de las mismas y aprovechando la testosterona libre que existe en el cuerpo. Esto es posible debido a los muchos caminos complejos que conducen a la producción de testosterona. Animal Stak funciona como un precursor hormonal, no sólo de testosterona sino también de la hormona del crecimiento. Contienen ingredientes como el tribulus terrestris, arginina, sustamina y zma, siendo una de las fórmulas más completas de las analizadas. Se puede combinar con Animal Test si quieres conseguir más resultados, ya que contienen ingredientes diferentes.

El Suplemento Natural de Testosterona tiene ingredientes como el Fenogreco, la Maca, Vitamina B6, el Ginseng, Zinc, L-Taurina, Pimienta Negra y Brócoli que son unos buenos suplementos deportivos. Además de ayudar al aumento de los niveles de testosterona, son buenos para potenciar la líbido sexual. Contiene compuestos bioactivos llamados saponinas esteroidales, que se cree que son los responsables de sus efectos beneficiosos en la salud.

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Es por ello que los deportistas optan cada vez más por este tipo de productos, especialmente en España. Ofrecemos constantes descuentos y promociones para todo el mundo, para pedidos al por mayor y para clientes habituales. Regístrarte a nuestra e-newsletter, para recibir semanalmente los mejores descuentos.

Newest Home loan Re-finance Prices inside the Colorado ()

Newest financial re-finance prices inside the Texas inform you a 30-12 months repaired Apr of six.43% and you will an excellent 15-season repaired Annual percentage rate of five.87%. Refinancing you can expect to decrease your monthly premiums, and then make homeownership a lot more in check.

By the Zachary Romeo, CBCA Assessed because of the Ramsey Coulter Edited by the Denise Cristobal By Zachary Romeo, CBCA Examined by Ramsey Coulter Modified by Denise Cristobal With this Page:

• Current Re-finance Cost in the CO
• Refinance Price Trend in the CO
• How to Re-finance for the CO
• When you should Refinance from inside the CO
• CO Mortgage Refinance Calculator
• Re-finance Costs because of the Credit history
• Re-finance Rates by the Financing Variety of
• FAQ

The modern mortgage refinance rate in the Colorado getting good fifteen-season fixed mortgage is actually 5.87%, when you’re a 30-seasons repaired loan is six.43%. In comparison, the federal averages for the very same financing designs try 5.38% and you will 6.45%, correspondingly.

We offer your into most recent insights and you will simple suggestions about refinancing their mortgage in Colorado. All of our rate reputation, pattern study and strategic advice on timing your own re-finance empower your into the studies you need to make informed refinancing conclusion.

MoneyGeek made use of Zillow investigation toward cost in this post. Just like the mortgage costs change each day, i have fun with a snapshot to analyze rate advice for Tx. I inform the knowledge seem to to make sure you have access to the newest rates, nevertheless the opinions may differ somewhat anywhere between revealing present. Unless listed otherwise, featured cost is actually yearly fee cost (APRs).

Newest Financial Re-finance Costs into the Texas

The present day 30-season re-finance speed within the Texas are 6.43%. Based on Experian, an average financial financial obligation inside Colorado is $333,814 by . By refinancing the financial, you might possibly lower your monthly premiums and relieve the notice paid down across the life of the mortgage.

To possess residents that have a high home loan speed, refinancing could offer good offers. Speak about the present day re-finance pricing in Tx lower than observe exactly how you could potentially work with.

Mortgage Re-finance Rate Style in the Texa

In the Colorado, 15-year refinance prices decreased out of 5.99% inside Oct in order to 5.78% inside the November. On the other hand, 30-12 months refinance costs displayed an upward direction of six.36% inside Oct to help you six.46% when you look at the November.

Interest rates increase for several causes, for instance the You Government Reserve’s financial plan and economic conditions. Regional issues may also impression re-finance price fashion into the Colorado. Facts these impacts helps you stand informed throughout the monetary change.

Just how to Refinance a mortgage for the Tx

Refinancing your home loan inside the Colorado can cause all the way down money and best words. Knowing the strategies in it is paramount to a smooth procedure. Mention the best way to build advised decisions and you may potentially save money in your home loan.

Check your Credit score

Credit scores determine financial pricing; increased get can also be secure greatest terms and conditions. When your get try reasonable, imagine paying down obligations or disputing inaccuracies. Colorado’s mediocre credit rating are 731, so aim to improve in case the score try lower than so it.

Dictate When to Re-finance a home loan

Determine your home loan words against market cost; Colorado’s fifteen-year fixed try 5.06%, 30-seasons repaired is actually 5.82%. In the event the speaking of all the way down, refinancing can get spend less. Consider carefully your home-stay cycle to make certain refinancing professionals outweigh the expense.

Collect Needed Records

Assemble crucial records such tax returns, shell out stubs and lender comments to suit your newest home loan. Which streamlines the brand new refinancing processes, making certain loan providers have all the required guidance to evaluate your application timely.

Research rates getting Loan providers

Exploring different lenders can be find out ideal rates and you can words. Discover aggressive interest rates, lower costs and you can positive customer critiques discover a loan provider one suits their refinancing demands.

See the Can cost you With it

Look for closing costs, including appraisal fees and you can label insurance rates. Depending on the Federal Association off Real estate professionals, an average closing costs from inside the Tx was $5,390.

Submit an application for the mortgage

Submit your application with all the called for documentspare also provides and select the best one. Pre-recognition can also be express this task, providing a sharper image of prospective financing terms and conditions and rates.

Lock in The Interest rate

After acknowledged, protected their rates to stop motion. Which ensures the rate stays steady until closure. Remember that timing is extremely important; locking into the from the right time can save money.

Intimate on your The fresh new Financing

Review and you can signal all of the closure records. Make sure the conditions suit your expectations. Delivering requisite personality and you may funds for settlement costs normally facilitate the fresh processes, so it is much easier much less exhausting.

Start making Payments in your The Mortgage

Begin costs given that booked to cease charges. Starting automated costs may help be sure you never ever miss an excellent due date, looking after your credit rating and you can financial balances.

Reassess When to Re-finance a home loan

Daily determine their mortgage terms against industry prices. If standards changes, refinancing once more would be useful. Being told on the business fashion makes it possible to create quick choices, optimizing your financial situation.

For the Tx, exactly how in the near future you could refinance home financing relies on the kind off financing. Getting old-fashioned money, refinancing can happen quickly. Although not, an earnings-away refinance demands a six-month flavoring months. USDA money generally need a good 12-day wishing several months just before refinancing.

The latest Oct refinance rate during the Tx fell to help you 5.82%, which is a good example of when to refinance, once the straight down prices renders refinancing more desirable. As you you may re-finance a mortgage in this a-year, it has been maybe not worth every penny because of the even more closing costs which can just take many years to recover. It is necessary to consider these will set you back as well as the possible savings away from a lower life expectancy interest rate to decide if refinancing is effective.

When you should Refinance home financing

Refinancing your own home loan inside Texas can lessen monthly payments from the decreasing interest levels. Although not, be mindful from closing costs which could offset offers. Accepting when you should refinance a home loan from inside the Colorado assures your enjoy economic professionals. See these circumstances in which refinancing could well be a smart selection:

All the way down Rates

Refinancing when interest levels lose can lessen monthly obligations and you may overall attention paid off. For the best cost, consult local lenders and you may credit unions, who usually provide competitive costs. Strengthening relationship with the institutions may cause custom offers.

Increased Home Worth

Refinancing should your house’s really worth rises is also boost family equity. Boosting control attract otherwise renovating kitchens can raise well worth. That have Colorado’s mediocre family well worth during the $550,511, you could safer finest loan terms.

Increased Credit rating

A top credit score is open straight down rates of interest. Spending expenses timely and you will reducing financial obligation can raise the rating. Which improve can result in extreme discounts across the life of the mortgage.

Reduced Financing Identity

Refinancing so you can a smaller loan title decrease full appeal and you can make collateral shorter. A good 15-seasons term commonly possess straight down rates, spending less fundamentally. This tactic is fantastic for people that are able higher monthly money.

Option Loan Form of

Altering regarding a varying-rate home loan (ARM) so you’re able to a fixed-price mortgage is balance out money. Fixed cost avoid market motion, giving predictable monthly expenses and you may much time-title economic planning professionals.

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SARMs Canada a vendre Acheté nos SARMs du Québec

Les auteurs de l’étude ont constaté que le taux de mortalité chez les participants sans SARM était d’environ 18%, mais que chez les porteurs du SARM, ce taux grimpait à 36%. Ce risque accru de décès prématurén’a pas été observé chez les participants porteurs de staphylocoques sur la peau, mais dénués de SARM. “Sans une stratégie uniforme, nous manquons une occasion d’aider à prévenir les décès causés par le SARM”, insiste le Pr Mainous. Crazy Bulk fait partie de ces fabricants qui ont compris que l’on pouvait avoir de très bons résultats avec des produits naturels. Ils ont ainsi développé des compléments alimentaires qui se positionnent comme une alternative aux produits dopants illégaux et dangereux pour la santé.

Aide à développer rapidement de la masse musculaire maigre

Le SARM se propage le plus souvent d’une personne à l’autre par contact direct avec une personne porteuse de la bactérie, habituellement par les mains. Il est maintenant présent dans la plupart des grands hôpitaux et dans presque toutes les régions de la province. La propagation du SARM dans les hôpitaux est difficile à contrôler, puisque les patients qui sont intubés, qui ont des cathéters ou des plaies ouvertes ont un risque élevé de développer une infection. Pour contenir la bactérie, il faut augmenter les mesures de dépistage, isoler les personnes infectées et resserrer les mesures d’hygiène.

Ce cycle de stack peut affecter la production de testostérone, c’est pourquoi une PCT est nécessaire pour éviter d’éventuels effets secondaires. Tous les produits ci-dessus suppriment la production de testostérone dans le corps, il est donc obligatoire d’exécuter le cycle PCT après eux. Pour information, Crazy Bulk est une entreprise qui connaît de plus en plus de succès, car leurs compléments alimentaires pour sportifs sont efficaces. De nombreux professionnels du sport les utilisent et sont très satisfaits de leurs produits. Ils sélectionnent des ingrédients naturels dont les effets ont le plus souvent été prouvés cliniquement. Les récepteurs modulateurs d’androgènes sélectifs (SARM’s) sont une classe de composés thérapeutiques qui ont des propriétés similaires à celles des agents anabolisants, mais avec des propriétés androgènes réduites.

• Le Rad-140 est considéré comme l’un des SARMs les plus puissants, possédant des effets anabolisants supérieurs à ceux du propionate de testostérone dans les essais sur les animaux (mg par mg).
• Le RAD 140 est un puissant agent anabolisant qui, outre une augmentation rapide de la masse musculaire sèche, donne également plus de dureté et de force aux muscles et permet une récupération rapide.
• En bref, les SARMs sont le plus souvent utilisés pour augmenter rapidement la masse musculaire.
• Crazy Bulk fait partie de ces fabricants qui ont compris que l’on pouvait avoir de très bons résultats avec des produits naturels.
• Il existe de nombreuses souches différentes de SARM, et la bactérie continue d’évoluer et de s’adapter.

Comment diagnostique-t-on une infection au SARM d’origine communautaire?

Il est important que les personnes qui pensent être atteintes d’une infection au SARM d’origine communautaire consultent rapidement un professionnel de la santé de façon à ce que l’infection puisse être bien diagnostiquée et traitée efficacement. Pour ce qui est des infections de la peau causées par cette bactérie, il est rare que des antibiotiques soient nécessaires. Une fois la blessure ouverte et le pus drainé, elle guérit normalement d’elle même. Un diagnostic précoce permet également de prendre les mesures appropriées pour limiter la propagation de l’infection.

Il n’y a rien de plus agaçant que la période de nettoyage du corps, où il faut se débarrasser de chaque kilo en trop sans perdre de masse musculaire. La manière unique dont fonctionnent les SARMs les rend adaptées au traitement d’un certain nombre de conditions médicales qui entraînent une diminution de la masse musculaire. Si vous êtes un fan de fitness et de sport, et qu’un mode de vie sain est quelque chose que vous aimez, alors vous avez probablement entendu parler des SARMs ou des modulateurs sélectifs des récepteurs androgènes. Les meilleurs SARM pour le développement de la masse musculaire sont le LGD-4033 et le RAD-140. Pour maximiser les gains, vous pouvez combiner les deux substances et ajouter de l’Ostarine/MK-677. En utilisant l’ensemble de la pile, vous pouvez vous attendre à une prise de poids d’environ 6 à 8 kg (personnes qui sont loin de leur maximum physiologique).

Principales causes des infections cutanées chez les Américains, les infections à staphylocoques sont généralement mineures. Le MK-677 est un peptide d’hormone de croissance développé par le groupe pharmaceutique Merck KGaA. Il ne s’agit pas d’un SARM, comme beaucoup le pensent, mais d’un sécrétagogue d’hormone de croissance HGH. Il ne se fixe pas sur les récepteurs androgènes et n’imite pas les effets des stéroïdes anabolisants.

Ce produit augmente les taux d’hormones https://tdhr.co.il/injection-de-steroides-pour-les-athletes/ de croissance dans le plasma sanguin. Sa particularité est qu’il n’affecte pas les niveaux de cortisol (l’hormone du stress). Les substances qui augmentent le taux de cortisol sont généralement très efficaces et à action rapide, mais elles ont généralement plusieurs effets secondaires. Ce n’est pas le cas de ce produit ; ses propriétés sont bénéfiques et durables.

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The summary of findings of the key outcomes of this meta-analysis has been elaborated in Table 3. Calibration and quality control (QC) samples were prepared in charcoal-stripped female human plasma and analyzed in each run. A 250 μl aliquot of sample was added to a glass screw-top tube followed by 750 μL of HPLC water, 100 μl of internal standard (IS) solution (d3-T/d3-DHT), and 4.0 ml of methyl-tert-butyl ether (MTBE).

• For electron microscopy, cells were harvested by tripsinization after 72 hr incubation with the compounds (25 μM), washed with sodium cacodilate (50 mM, pH 7.4), fixed with 1.25% glutaraldehyde/4% paraformaldehyde and preserved at 4°C for further processing.
• After a median follow-up of 55.7 months, the trial demonstrated a significant reduction in events (recurrence, contralateral breast cancer, or death) in favor of the exemestane arm (Coombes et al 2007).
• AIs are now considered to be the standard of care for postmenopausal women with hormone receptor-positive breast cancer 16.
• This breakthrough has sparked and inspired the later development of a wide variety of AIs.
• This gives users peace of mind knowing that they are getting a product that is backed by a reputable and experienced manufacturer.

Adjuvant Setting

Aromasin (exemestane) is a member of the aromatase inhibitors drug class and is commonly used for Breast Cancer. Possible side effects of aromatase inhibitors include muscle pain, joint pain and menopausal symptoms (such as hot flashes). There is no increase in uterine cancers or thromboembolic events as is observed with tamoxifen, but with the exception of hot flushes. Women taking AIs are more likely to complain of symptoms related to estrogen deprivation. Women taking AIs are also more likely to report musculoskeletal adverse events than women taking tamoxifen. Patients react differently to aromatase inhibitors, but few experience side effects severe enough to interfere with daily life.

Head-to-head comparisons of an aromatase inhibitor and tamoxifen

Likewise, men with low zinc levels consistently display lower androgen level readings, illustrating a definitive association between these two micronutrients and sex hormone levels. Healthy young men who followed a zinc-restricted diet for 20 weeks experienced a drastic decrease in total testosterone levels, falling to a mere 25% of baseline values 5. Olaparib (Lynparza) is a targeted therapy approved by the Food and Drug Administration that is used to treat early-stage or metastatic breast cancer with Post cycle therapy buy specific parameters. Doctors should inform us about expected side effects and dedicate time to discuss mitigation strategies.

Analysis of protein expression levels (figure 2B) in the tumors at the end of treatment showed reduced levels of HER2 with trastuzumab alone or in combination and increased expression of ER. However, in presence of the combined treatment, the effect of trastuzumab to increase ER expression and aromatase was blocked by letrozole resulting in reduced tumor growth (figure 2A). Preclinical studies indicate that AIs might be effective in reducing the risk of breast cancer in hormonally intact animals under circumstances in which breast aromatase is up-regulated (88).

The IC50 value for hit compound 38 of 52 nM was compared with the reference drug Combretastatin A4—3.9 nM 36. Aromatase is a human enzyme belonging to the family of cytochromes P450, constituting the product of expression of the CYP19A1 gene, located on the 15th chromosome 4,5. Its role in the human body is related to the catalysis of the last stage of estrogen biosynthesis.

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La compressa può essere assunta sia vicino sia lontano dai pasti, deve essere deglutita intera con acqua o con un altro liquido. La dose abituale è di una compressa al giorno contenente una quantità di principio attivo pari a 2,5 mg, è consigliata l’assunzione alla stessa ora del giorno. La durata del trattamento viene stabilita dal medico oncologo in base al tipo di tumore e alle condizioni cliniche della paziente. Qualora si dimentichi di assumere una compressa, non bisogna assolutamente assumere una dose doppia di farmaco per compensare la dimenticanza, ma deve essere subito informato il medico oncologo che deciderà il da farsi.

Posso assumere le compresse di letrozolo da 2.5 mg dopo l’ovulazione?

• Il letrozolo è un inibitore dell’aromatasi, una classe di farmaci utilizzati principalmente nel trattamento del tumore al seno ormono-dipendente nelle donne in post-menopausa.
• La durata del trattamento viene stabilita dal medico oncologo in base al tipo di tumore e alle condizioni cliniche della paziente.
• Qualora la terapia con letrozolo provochi una riduzione della densità minerale ossea, l’oncologo saprà prescrivere i rimedi più efficaci per contrastarla.rete.
• Per le donne con problemi di infertilità, può stimolare l’ovulazione e aumentare le possibilità di concepimento.

Tuttavia, la sua applicazione principale rimane quella oncologica, dove ha dimostrato efficacia e sicurezza nel lungo termine. Il letrozolo può essere somministrato per diversi mesi o anni a seconda della vostra particolare situazione. L’oncologo che vi ha in cura discuterà con voi quella che https://bivits.ba/blog/ghrp-6-10-mg-peptide-sciences-azione-e-benefici-2/ a suo parere è la durata del trattamento più indicata per il vostro caso. Il letrozolo può provocare questi disturbi; nella maggior parte dei casi è sufficiente assumere analgesici.

Consultare sempre un medico prima di usare il letrozolo per scopi di fertilità. Per l’induzione dell’ovulazione, w viene solitamente prescritto a una dose di 2.5 mg al giorno per cinque giorni, a partire dal terzo o quinto giorno del ciclo mestruale. Tuttavia, i dosaggi possono variare in base alle condizioni mediche individuali e alle risposte al trattamento. Il letrozolo è controindicato in pazienti pre-menopausali, in gravidanza e durante l’allattamento, poiché può causare danni al feto o al neonato.

Se questi sintomi compaiono, potrebbero essere alleviati dall’assunzione del farmaco all’ora dei pasti o prima di coricarsi. Il vomito può essere trattato con farmaci antiemetici e la diarrea con farmaci antidiarroici. Il trattamento con letrozolo può scatenare reazioni cutanee che si manifestano sotto forma di arrossamenti, rash, orticaria, vescicole a labbra, occhi o gola, desquamazione della pelle ed eritemi.

Alcuni effetti indesiderati possono essere gravi:

2 Stratificati in base allo stato del recettore, lo stato linfonodale e precedente chemioterapia adiuvante. La cimetidina, un inibitore debole aspecifico degli enzimi CYP450, non ha influenzato le concentrazioni plasmatiche del letrozolo. Indotta, dopo ripresa o progressione della malattia che siano state trattate in precedenza con antiestrogeni.

La terapia con letrozolo può causare stanchezza e debolezza, talvolta accompagnate da capogiri e cefalea. L’aromatasi è un enzima che riveste un ruolo fondamentale nella sintesi degli estrogeni (ormoni sessuali femminili). Il letrozolo viene solitamente assunto all’inizio del ciclo mestruale, solitamente per cinque giorni a partire dal secondo o terzo giorno, per stimolare l’ovulazione. Seguire sempre le istruzioni del proprio medico per quanto riguarda tempi e dosaggio.

Questa specificità garantisce che l’azione del farmaco sia concentrata sull’inibizione dell’aromatasi, con minori effetti su altri sistemi ormonali. Le frequenze delle reazioni avverse per letrozolo sono principalmente basate su dati raccolti da studi clinici. Le seguenti reazioni avverse, elencate in Tabella 1, sono state segnalate dagli studi clinici e dall’esperienza successiva alla commercializzazione di letrozolo. Di seguito sono riportati i principali effetti collaterali che possono insorgere in seguito alla chemioterapia con letrozolo. Il letrozolo – come tutti i farmaci antitumorali – può indurre svariati effetti collaterali.

Nel sottostudio per la valutazione dell’osso MA-17 in cui sono stati somministrati in concomitanza calcio e vitamina D, si è verificata una maggiore riduzione della densità minerale ossea (BMD) rispetto al basale con letrozolo confrontata con il placebo. La sola differenza statisticamente significativa verificatasi a 2 anni era nella BMD totale dell’anca (diminuzione mediana con letrozolo di 3,8% verso diminuzione mediana con placebo di 2,0%). Né i livelli plasmatici di LH e FSH, la funzione tiroidea, valutata in base al TSH e al test dell’uptake di T4 e T3, vengono influenzati dal letrozolo. Fino a circa un terzo delle pazienti trattate con letrozolo nella fase metastatica e circa l’80% delle pazienti in trattamento adiuvante, cosi come nel trattamento adiuvante dopo terapia standard con tamoxifene, hanno manifestato delle reazioni avverse. La maggior parte delle reazioni avverse si sono manifestate durante le prime settimane di trattamento. Il metabolismo di letrozolo è mediato – a livello epatico – principalmente dal citocromo P3A4, un isoenzima del citocromo P450.

L’utilizzo di letrozolo può causare ipercolesterolemia; è, pertanto, necessario un attento monitoraggio dei livelli ematici di colesterolo durante tutto il periodo di trattamento con il farmaco. Il letrozolo può alterare lievemente la capacità di guidare veicoli o di usare macchinari, in quanto può causare stanchezza e capogiri. In caso di preesistenti patologie epatiche e/o renali, è necessario informarne il medico oncologo che ne terrà conto durante la somministrazione del farmaco. Il letrozolo non deve assolutamente essere utilizzato in bambini e adolescenti. L’uso di letrozolo senza necessità terapeutica costituisce doping e, comunque – anche se il farmaco è utilizzato a dosi terapeutiche – può dare positività ai test anti-doping.

Pertanto, deve essere usata cautela qualora sia necessario somministrare il letrozolo in concomitanza con medicinali la cui eliminazione dipende soprattutto da questi isoenzimi e il cui indice terapeutico è ristretto ( es. fenitoina e clopidogel). Poiché le compresse contengono lattosio, letrozolo non è raccomandato per pazienti affette da rari problemi ereditari di intolleranza al galattosio, da gravi deficit di lattasi o da malassorbimento di glucosio-galattosio. Letrozolo SUN 2,5 mg compresse rivestite con film sono compresse di colore giallo scuro, rotonde, biconvesse, lisce su entrambi i lati. Il letrozolo può provocare un’aumentata frequenza della minzione e/o favorire l’insorgenza d’infezioni del tratto urinario.